Gregory W. Moseley

This paper shows that the rabies virus P protein selectively inhibits certain IFN-stimulated and repressed genes while allowing others, demonstrating that IFN-antagonists can modulate specific pathways rather than globally suppressing IFN signaling.

This study reveals how rabies virus P protein inhibits interferon signaling by selectively binding to phosphorylated STAT1 tetramers, stabilizing them and preventing DNA binding.