Paul R. Gooley

This study compares the conformational diversity of α1A-Adrenoceptor in different membrane mimetics using NMR, showing that SNPs reduce conformational dynamics compared to detergents.

This paper shows that the rabies virus P protein selectively inhibits certain IFN-stimulated and repressed genes while allowing others, demonstrating that IFN-antagonists can modulate specific pathways rather than globally suppressing IFN signaling.

This study reveals how rabies virus P protein inhibits interferon signaling by selectively binding to phosphorylated STAT1 tetramers, stabilizing them and preventing DNA binding.

This paper investigates the allosteric mechanism of GPCRs, finding that both peptide- and small-molecule-activated GPCRs use an induced-fit mechanism rather than conformational selection.