A mutation rate model at the basepair resolution identifies the mutagenic effect of Polymerase III transcription
Vladimir B. Seplyarskiy, Evan M Koch, Daniel J. Lee, Joshua S. Lichtman, Harding H. Luan, Shamil R. Sunyaev
The paper introduces a basepair-resolution mutation rate model, Roulette, which identifies a 10-fold increase in mutation rate for Polymerase III-transcribed genes and detects elevated rates in testis-specific transcription factor binding sites.
Nature Genetics · Nov 30, 2023Peer-reviewedGenetics