Daniel J. Lee

The paper introduces a basepair-resolution mutation rate model, Roulette, which identifies a 10-fold increase in mutation rate for Polymerase III-transcribed genes and detects elevated rates in testis-specific transcription factor binding sites.

The paper shows GATA6 and NANOG bind shared regulatory elements to drive divergent cell fates in mouse blastocysts by modulating chromatin accessibility and transcriptional activation.

The paper characterizes the epigenomic landscape of embryonic mouse forebrain neural progenitors using snATAC-Seq and integrates multi-omics data to reveal region-specific regulatory mechanisms.