Henk Roelink

Non-cell autonomous inhibition of the Shh pathway due to impaired cholesterol biosynthesis requires Ptch1/2

The paper shows that mutations in cholesterol synthesis genes impair Shh signaling in neighboring cells via Ptch1/2 efflux of cholesterol precursors.

Association of Sonic Hedgehog with the Extracellular Matrix Requires its Putative Zinc-Peptidase Activity

This study shows that Sonic Hedgehog's zinc-coordination fold is necessary for its association with the extracellular matrix and non-cell autonomous signaling.

Gain-of-function Shh mutants activate Smo in cis independent of Ptch1/2 function

The paper identifies Shh mutations that enable cell-autonomous activation of the Hh pathway via Smo, independent of Ptch1/2, and shows that unprocessed Shh pro-peptide can drive this activation.