Cell BiologybioRxivPreprint
Colchicine Directly Targets Aldehyde Dehydrogenase 2 (ALDH2) to Suppress Radiation-Induced Senescence and Atherosclerosis
Jun‐ichi Abe, Venkata Subrahman K Samanthapudi, Weiqing Chen…·Sivareddy Kotla
This study identifies ALDH2 as a direct target of colchicine, showing it suppresses radiation-induced senescence and atherosclerosis by modulating mitochondrial redox and macrophage function.
DOI 10.64898/2026.05.25.726409