Human Norovirus NS7 Protein Activates Canonical Inflammasome Pathways via NLRP6 in Intestinal Epithelial Cells
Sunghoon Park, Sung-Gyu Cho, Hyeon Woo Chung, Hwang Su Jin, Tae‐Hee Kim, Jae Myun Lee
This study identifies the HNoV NS7 protein as a direct activator of NLRP6 and NLRP3 inflammasomes in intestinal epithelial cells, revealing NLRP6's critical role in antiviral defense against norovirus.
bioRxiv · Nov 7, 2025 · PreprintImmunology