Activity deprivation modulates the Shank3/Homer1/mGluR5 signaling pathway to enable synaptic upscaling
Andrea A. Guerrero, Gina G. Turrigiano
This study shows that dephosphorylation of Shank3 remodels the Shank3/Homer1/mGluR signaling pathway to enable synaptic upscaling by favoring agonist-dependent mGluR signaling.
Journal of Neuroscience · Oct 3, 2025Peer-reviewedNeuroscience