Gina G. Turrigiano

Prey capture learning drives critical period-specific plasticity in mouse binocular visual cortex

This study shows that prey capture learning during the critical period in mice enhances visual function through structural plasticity, including increased excitatory connectivity and spine turnover, which is absent in adults.

Activity deprivation modulates the Shank3/Homer1/mGluR5 signaling pathway to enable synaptic upscaling

This study shows that dephosphorylation of Shank3 remodels the Shank3/Homer1/mGluR signaling pathway to enable synaptic upscaling by favoring agonist-dependent mGluR signaling.

Learning-Associated Flexibility of Cortical Taste Coding Is Impaired in Shank3 Knockout Mice

This study shows that Shank3 knockout mice have impaired cortical taste coding flexibility during learning, leading to slower conditioned taste aversion acquisition.

Modular Arrangement of Synaptic and Intrinsic Homeostatic Plasticity within Visual Cortical Circuits

The paper investigates whether synaptic scaling and intrinsic homeostatic plasticity act redundantly or independently in rodent visual cortex, finding they can be independently recruited to stabilize different network features.

Rapid prey capture learning drives a slow resetting of network activity in rodent binocular visual cortex

This study shows that learning in juvenile rats leads to a slow increase in firing rates in V1b neurons, driven by homeostatic plasticity mechanisms.

Cholinergic Modulation is Necessary for Upward Firing Rate Homeostasis in Rodent Visual Cortex

This study shows that cholinergic modulation is necessary for upward firing rate homeostasis in rodent visual cortex during active wake, but not during quiet wake.

Juvenile Shank3 KO mice adopt distinct hunting strategies during prey capture learning

This study examines how juvenile Shank3 knockout mice differ in hunting strategies compared to wild-type mice, revealing behavioral patterns similar to those seen in individuals with autism spectrum disorder.

A Bidirectional Switch in the Shank3 Phosphorylation State Biases Synapses toward Up or Down Scaling

This study identifies bidirectional phosphorylation changes in Shank3 that regulate synaptic scaling up or down in mouse and rat neurons.

Strong Aversive Conditioning Triggers a Long-Lasting Generalized Aversion

This study shows that strong aversive conditioning leads to long-lasting generalized aversion, with synaptic plasticity in different brain layers governing memory persistence and generalization.

Developmental Regulation of Homeostatic Plasticity in Mouse Primary Visual Cortex

This study investigates how homeostatic plasticity mechanisms differ in mouse primary visual cortex during development and adulthood using DREADD-mediated activity suppression.

Homeostatic Synaptic Scaling Establishes the Specificity of an Associative Memory

This study shows that synaptic scaling is crucial for making associative memories specific, as blocking it leads to generalized aversion and prolonged synaptic strength increases in conditioned taste aversion memory.

Ciliary neuropeptidergic signaling dynamically regulates excitatory synapses in postnatal neocortical pyramidal neurons

This study shows that ciliary neuropeptidergic signaling dynamically modulates excitatory synapses in postnatal neocortical pyramidal neurons, with SSTR3 playing a key role.

Stability of neocortical synapses across sleep and wake

This study investigates whether sleep and wake states drive changes in neocortical synaptic strength in juvenile rats, finding no significant changes in synaptic strength across these states.

Activity labeling in vivo using CaMPARI2 reveals electrophysiological differences between neurons with high and low firing rate set points

The paper uses CaMPARI2 to label neurons based on firing rates and finds that high activity neurons in mouse V1 have increased intrinsic excitability and lower spike adaptation, contributing to higher firing rate set points.

Sleep promotes downward firing rate homeostasis

The paper demonstrates that sleep enables downward firing rate homeostasis, which is distinct from upward homeostasis and occurs during sleep rather than wake.

Homeostatic mechanisms regulate distinct aspects of cortical circuit dynamics

This study identifies how homeostatic mechanisms regulate higher-order network properties in rodents during visual deprivation, revealing distinct roles for synaptic scaling and intrinsic plasticity.

Rapid and Active Stabilization of Visual Cortical Firing Rates Across Light-Dark Transitions

This study shows that V1 neurons maintain stable firing rates during expected light-dark transitions but respond to unexpected changes, with correlations during natural vision being more informative than individual rates.

Critical dynamics are a homeostatic set point of cortical networks in vivo.

The paper shows cortical networks maintain critical dynamics independently of excitatory firing rate homeostasis, with inhibitory neurons playing a key role in stabilizing this state.

Autism-associated Shank3 is essential for homeostatic plasticity and neuronal circuit stability

This study shows that Shank3 loss disrupts homeostatic plasticity and circuit stability, which can be rescued by lithium, suggesting a therapeutic target for Shankopathies.

Sensory Deprivation Independently Regulates Neocortical Feedforward and Feedback Excitation-Inhibition Ratio

The paper shows that sensory deprivation alters both feedforward and feedback excitation-inhibition ratios in layer 4 of V1, with feedback inhibition primarily causing reduced visual responsiveness.