ACE2 decoy Fc-fusions and bi-specific killer engager (BiKEs) require Fc engagement for in vivo efficacy against SARS-CoV-2
Jenna K. Dick, Venkatramana Divana Krishna, Dustin Hicks, Jules A. Sangala, Robert J. Oldham, Benjamin T. Zandstra, Carly Baehr, J. Sjef Verbeek, Mark Steven Cragg, Marco Pravetoni, Maxim C.‐J. Cheeran, Geoffrey T. Hart
This study shows that Fc receptor engagement is necessary for the efficacy of SARS-CoV-2 therapeutics, including mAbs and BiKEs, and demonstrates the effectiveness of ACE2 decoy Fc-fusions and BiKEs against multiple variants.
The Journal of Immunology · Aug 1, 2026Peer-reviewedImmunology