Author

Eric D. Kelsic

Harvard UniversityORCID 0000-0002-5331-5204Unclaimed ORCID profile · follow to get notified of new preprints

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Eric D. Kelsic1 paper

Biology Disciplines

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Evolutionary Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:machine learning (classical)· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Assay:proteomics· 1 Approach:variational autoencoder· 1

Frequent Co-Authors

Nina K. JainiD· 2 shared Sam SinaiiD· 2 shared Ali BashiriD· 1 shared Andreea Gane· 1 shared Drew BryantiD· 1 shared George M. ChurchiD· 1 shared George McDonald ChurchiD· 1 shared Lucy J. ColwelliD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 30 mutual co-author links

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2 shared papersEvolutionary Biology

Nina K. JainORCID

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2 papers

Recent·Most cited

A Vast Navigable Protein Sequence Subspace

Sam Sinai, Andreea Gane, Nina K. Jain, Drew Bryant, Maxwell L. Bileschi, Ali Bashir, George M. Church, Eric D. Kelsic, Lucy J. Colwell

The paper maps the genome packaging landscape of AAV2 capsid protein using high-throughput synthesis and machine learning, revealing navigable subspaces of functionally viable sequences.

bioRxiv · Oct 22, 2026 · PreprintEvolutionary Biology

Generative AAV capsid diversification by latent interpolation

Sam Sinai, Nina K. Jain, George McDonald Church, Eric D. Kelsic

The paper uses a Variational Auto-encoder to generate diverse AAV capsid variants with potential immune evasion properties by interpolating in sequence space.

bioRxiv · Apr 16, 2021 · PreprintSynthetic Biology