George McDonald Church

PG-LLM benchmarks language models for protein variant ranking, showing they outperform many sequence-based predictors but fall short of specialized models.

This study uses paleogenomes of dire wolves to resolve their evolutionary relationships and identify genes under diversifying selection.

This paper presents a single-cell atlas of skin aging and identifies ATF3 as a regulator of aging, leading to an mRNA-based treatment that reduces cell senescence and enhances skin rejuvenation.

The paper examines motivations and outcomes of elective genomic sequencing across research, clinical, and commercial contexts, finding most participants found results medically important but few shared them with healthcare providers.

This paper reports the first derivation of elephant induced pluripotent stem cells (emiPSCs) using a modified reprogramming protocol that inhibits TP53 expansion genes.

This paper introduces SONAR, a platform for detecting nucleic acids and triggering gene expression in human cells, demonstrating its ability to sense DNA and RNA and express various protein payloads.

The paper analyzes single-cell multiome data from human HSPCs to show aging-related rewiring of gene regulatory networks, leading to stress hyperactivation, myeloid bias, and identity loss.

This paper introduces a method using single-stranded DNA templates and bacteriophage RNA polymerases to produce functional RNAs in mammalian cells, demonstrating applications in CRISPR-based genome editing.

The paper demonstrates DNA cyclization efficiencies exceeding classical Jacobson-Stockmayer predictions by over threefold using optimized enzyme combinations.

This paper introduces AminoX, a platform for programmable covalent protein design using non-standard amino acids, enabling efficient screening and functional validation of covalent warheads and multifunctional proteins.

The paper analyzes nucleic acid sequences from the Zag meteorite, showing they lack biological coding features but exhibit constrained complexity, suggesting non-biological or unknown origins.

This paper introduces genetic devices for precise control of cell-type ratios and multicellular morphology in synthetic biology systems.

This study develops a high-throughput platform using human cerebral organoids to screen for compounds that reverse HSV-1-induced neuroinflammation biomarkers associated with Alzheimer's disease.

The paper introduces AtomPaint, a full-atom diffusion model for designing protein/non-protein binding interactions, showing it outperforms random guessing in sequence recovery.

This study shows that single nutrients do not determine breast cancer metastasis sites, and identifies purine synthesis as a key factor across multiple tissues.

XTree aligns sequencing reads to large genome databases efficiently and accurately, outperforming existing tools in precision and recall.

This paper introduces OPENER, an engineered eRF1 variant that suppresses nonsense mutations and enables nonstandard amino acid incorporation, showing therapeutic benefits in a Duchenne muscular dystrophy model.

This study develops an orthogonal translation initiation system using an i-tRNA-AAC mutant and evaluates its physiological impact through fluorescence assays, proteomics, and tRNA sequencing.

This paper introduces an enzyme-free oxygen-scavenging buffer for DNA-PAINT imaging that improves stability, reduces costs, and extends imaging duration.

The paper introduces Korea10K, a large genomic dataset of 10,239 Korean genomes with multiomic and clinical data, enabling population-specific variant imputation and insights into genomic-epigenomic regulation.

The paper describes the creation of SINERGY, a synthetic sourdough starter using engineered microbial consortia with division-of-labor modules for biosensing and drug delivery.

The paper develops and characterizes gene drive docking lines in Anopheles gambiae using RMCE and HACK techniques, identifies challenges for robust gene drive development.

The paper introduces PRISM, a platform that uses combinatorial protein barcodes to enable self-correcting neuron tracing with molecular context, improving tracing accuracy and handling spatial gaps.

This study identifies suitable tRNA sources for cell-free protein synthesis by evaluating tRNA pools from different E. coli strains and V. natriegens, finding that A19 tRNAs are most effective for in vitro translation.

The paper designs and evaluates recombinase-based genetic programs in human cells that simulate a for-loop counting to three, demonstrating heritable memory and sequential gene expression.

SAHA creates a multimodal, subcellular-resolution reference atlas of healthy human tissues, revealing spatial organization and disease-associated disruptions across multiple organ systems.

The paper introduces a machine-learning pipeline, CellCartographer, to design TF pooled-screens for cell type conversion using chromatin accessibility data, achieving efficient differentiation of iPSCs into six cell types within 6 days.

This study shows that polyacrylamide hydrogels support DNA-PAINT imaging by preserving nanoscale docking strand positioning and enhancing diffusion and accessibility.

This study develops a midbrain organoid model for bipolar disorder using patient-derived hiPSCs, identifies dysregulated signaling pathways, and shows lithium reverses some abnormalities.