Author

Sam Sinai

Harvard UniversityORCID 0000-0003-0301-9201Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Evolutionary Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:machine learning (classical)· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Assay:proteomics· 1 Approach:variational autoencoder· 1

Frequent Co-Authors

Eric D. KelsiciD· 2 shared Nina K. JainiD· 2 shared Ali BashiriD· 1 shared Andreea Gane· 1 shared Drew BryantiD· 1 shared George M. ChurchiD· 1 shared George McDonald ChurchiD· 1 shared Lucy J. ColwelliD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 30 mutual co-author links

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2 shared papersEvolutionary Biology

Eric D. KelsicORCID

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2 papers

Recent·Most cited

Evolutionary BiologybioRxivPreprintOct 22, 2026

A Vast Navigable Protein Sequence Subspace

Sam Sinai, Andreea Gane, Nina K. Jain…·Lucy J. Colwell

The paper maps the genome packaging landscape of AAV2 capsid protein using high-throughput synthesis and machine learning, revealing navigable subspaces of functionally viable sequences.

DOI 10.64898/2026.10.18.759989

proteomicsmachine learning (classical)

𝕏 PostBluesky

Synthetic BiologybioRxivPreprintApr 16, 2021

Generative AAV capsid diversification by latent interpolation

Sam Sinai, Nina K. Jain, George McDonald Church, Eric D. Kelsic

The paper uses a Variational Auto-encoder to generate diverse AAV capsid variants with potential immune evasion properties by interpolating in sequence space.

33 citations

protein sequencevariational autoencoder

𝕏 PostBluesky