Manganese-dependent microRNA trimming by 3'->5' exonucleases generates 14-nucleotide or shorter tiny RNAs
GeunYoung Sim, Audrey C. Kehling, Mi Seul Park, Jackson Secor, Cameron Divoky, Huaqun Zhang, Nipun Malhotra, Divyaa Bhagdikar, Ekram W. Abd El-Wahab, Kotaro Nakanishi
The paper identifies manganese-dependent 3'->5' exonucleases that trim miRNAs to generate short tyRNAs, revealing their role in AGO3 slicer activity and gene silencing under stress conditions.
Proceedings of the National Academy of Sciences · Dec 12, 2022Peer-reviewedMolecular Biology