Author

GeunYoung Sim

Cold Spring Harbor LaboratoryORCID 0000-0002-4850-6348Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Adrian R. KraineriD· 1 shared Alexander J. KraliD· 1 shared Audrey C. KehlingiD· 1 shared Cameron DivokyiD· 1 shared Divyaa BhagdikariD· 1 shared Ekram W. Abd El-Wahab· 1 shared Huaqun ZhangiD· 1 shared Jackson SecoriD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

Adrian R. KrainerORCID

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2 papers

Recent·Most cited

Splice-switching ASOs targeting an Alu-derived exon in the AURKA 5'UTR collapse an SRSF1-AURKA-MYC oncogenic circuit in pancreatic cancer

Alexander J. Kral, Lu Jia, GeunYoung Sim, Ledong Wan, Adrian R. Krainer

This study identifies an SRSF1-AURKA-MYC oncogenic circuit in pancreatic cancer and shows that splice-switching ASOs targeting AURKA 5'UTR splicing disrupts this circuit, reducing cell viability and inducing apoptosis.

bioRxiv · Apr 14, 2025 · PreprintCancer Biology

Manganese-dependent microRNA trimming by 3'->5' exonucleases generates 14-nucleotide or shorter tiny RNAs

GeunYoung Sim, Audrey C. Kehling, Mi Seul Park, Jackson Secor, Cameron Divoky, Huaqun Zhang, Nipun Malhotra, Divyaa Bhagdikar, Ekram W. Abd El-Wahab, Kotaro Nakanishi

The paper identifies manganese-dependent 3'->5' exonucleases that trim miRNAs to generate short tyRNAs, revealing their role in AGO3 slicer activity and gene silencing under stress conditions.

Proceedings of the National Academy of Sciences · Dec 12, 2022Peer-reviewedMolecular Biology