Author

Lynette Grant Sadleir

University of OtagoORCID 0000-0002-5355-7115Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:GWAS / association mapping· 1 Assay:GWAS summary statistics· 1

Frequent Co-Authors

Ingrid Eileen SchefferiD· 3 shared Gaëtan LescaiD· 2 shared Gemma L. CarvilliD· 2 shared Heather C. MeffordiD· 2 shared Michael S. HildebrandiD· 2 shared Adam P. VogeliD· 1 shared Agnieszka GidzielaiD· 1 shared Alena Jahodová· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersGenetic & Genomic Medicine

Ingrid Eileen SchefferORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Unravelling the genetic basis of stuttering: GWAS meta-analysis highlights link with rare speech disorders

Victoria E. Jackson, Jenna J. Shin, Sarah Horton, Jessica O. Boyce, Else Eising, Olivia van Reyk, Richard Parker, Daisy G.Y. Thompson-Lake, Meghan Evans, Janet M. Beilby, Jennifer Elizabeth Below, Dorret Irene Boomsma, Elinor C. Bridges, Elizabeth C. Corfield, Marie-Christine J. P. Franken, , Melanie Bahlo

This study conducts a GWAS meta-analysis of stuttering, identifying genetic links with speech disorders and highlighting shared genetic architecture across different ascertainment methods.

medRxiv · Sep 16, 2026 · PreprintGenetic & Genomic Medicine

Diagnostic Utility of Genome-wide DNA Methylation Analysis in Genetically Unsolved Developmental and Epileptic Encephalopathies and Refinement of a CHD2 Episignature

Christy W. LaFlamme, Cassandra Rastin, Soham Sengupta, Helen E. Pennington, Sophie J. Russ-Hall, Amy Schneider, Emily S. Bonkowski, Edith P. Almanza Fuerte, Talia J. Allan, Miranda Galey, Joy Goffena, Sophia B Gibson, Denis M. Nyaga, Nico Lieffering, Malavika Hebbar, , Heather C. Mefford

This study evaluates genome-wide DNA methylation analysis in genetically unsolved DEEs, identifying 10 causative or candidate genetic causes and refining a CHD2 episignature.

Nature Communications · Aug 6, 2024Peer-reviewedGenetic & Genomic Medicine

Missense variants in the voltage sensing and pore domain of KCNH5 cause neurodevelopmental phenotypes including epilepsy

Hannah C. Happ, Lynette Grant Sadleir, Matthew Zemel, Guillem de Valles‐Ibáñez, Michael S. Hildebrand, Allyn McConkie‐Rosell, Marie McDonald, Halie J. May, Tristan T. Sands, Vimla S. Aggarwal, Christopher J. Elder, Timothy J. Feyma, Allan Bayat, Rikke Steensbjerre Møller, Christina Fenger, , Gemma L. Carvill

The paper reports a cohort of 17 patients with pathogenic KCNH5 variants causing neurodevelopmental disorders and epilepsy, identifying genotype-phenotype correlations.

medRxiv · Apr 26, 2022 · PreprintGenetic & Genomic Medicine