Fiber alignment alone is insufficient to predict cellular contact guidance responses in engineered 3D collagen hydrogels
Poorya Esmaili, Tresa M. Elias, Indranil M. Joshi, Richard A. Simon, Dinindu De Silva, Sami Farajollahi, Olivia M Harris, Edward B. Brown, Vinay V. Abhyankar
The paper shows that collagen fiber alignment alone cannot predict cellular contact guidance responses, as migration behavior varies with the second harmonic generation forward-to-backward ratio (F/B) in 3D collagen hydrogels.
bioRxiv · Sep 30, 2026 · PreprintBioengineering