Engineering the smallest transcription factor: accelerated evolution of a 63-amino acid peptide dual activator-repressor
Andreas K. Brödel, Rui Rodrigues, Alfonso Jaramillo, Mark Isalan
This paper engineers a 63-amino acid peptide that functions as both an activator and repressor, demonstrating that minimal transcription factor activity is achievable through directed evolution.
bioRxiv · Aug 5, 2019 · PreprintSynthetic Biology