Author

Andreas K. Brödel

Eligo Bioscience (France)ORCID 0000-0002-8639-9782Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Organism:mouse· 1 Research Focus:protein design· 1 Assay:protein sequence· 1

Frequent Co-Authors

Chloé Poquet· 2 shared Dalila Spadoni· 2 shared David BikardiD· 2 shared Edith M. HesseliD· 2 shared Fabien J. FucheiD· 2 shared Gautier Prevot· 2 shared Jesús Fernández-RodrígueziD· 2 shared Loïc H. Charpenay· 2 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersSynthetic Biology

Chloé Poquet

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Treatment of STEC infection via CRISPR-Cas targeted cleavage of the Shiga toxin gene in animal models

Matthieu Galtier, Antonina O. Krawczyk, Fabien J. Fuche, Loïc H. Charpenay, Igor Stzepourginski, Simone Pignotti, Marion Arraou, Rémi Terrasse, Andreas K. Brödel, Chloé Poquet, Gautier Prevot, Dalila Spadoni, Benjamin Buhot, Kristin Munch, Jan Havránek, , Jesús Fernández-Rodríguez

This paper develops a CRISPR-based therapy targeting Shiga toxin genes in STEC infections, showing efficacy in reducing bacterial load and mitigating disease in animal models.

bioRxiv · Feb 28, 2025 · PreprintSynthetic Biology

In situ targeted mutagenesis of gut bacteria

Andreas K. Brödel, Loïc H. Charpenay, Matthieu Galtier, Fabien J. Fuche, Rémi Terrasse, Chloé Poquet, Marion Arraou, Gautier Prevot, Dalila Spadoni, Edith M. Hessel, Jesús Fernández-Rodríguez, Xavier Duportet, David Bikard

This paper develops a method to edit bacterial genes in the gut using a phage-derived particle, achieving high editing efficiency and stable maintenance of modified bacteria.

bioRxiv · Sep 30, 2022 · PreprintSynthetic Biology

Engineering the smallest transcription factor: accelerated evolution of a 63-amino acid peptide dual activator-repressor

Andreas K. Brödel, Rui Rodrigues, Alfonso Jaramillo, Mark Isalan

This paper engineers a 63-amino acid peptide that functions as both an activator and repressor, demonstrating that minimal transcription factor activity is achievable through directed evolution.

bioRxiv · Aug 5, 2019 · PreprintSynthetic Biology