Jonathan E. Barnes

This paper trains a neural network to correct FoldX's free energy predictions for protein folding and binding, significantly improving accuracy for single and double mutations and epistasis.

This study shows deep-sea fish larvae use a hybrid cone-rod photoreceptor type for vision in dim light, revealing an alternative developmental pathway for vertebrate vision.

This study evaluates the MD+FoldX method's ability to predict SARS-CoV-2 antibody escape mutations using a large deep mutational scanning dataset, showing moderate correlation with experimental data.

This study identifies molecular mechanisms behind spectral shifts in zebrafish cone opsins using molecular modeling and quantum mechanics, highlighting key residues and structural features responsible for different absorption wavelengths.