Jagdish Suresh Patel

This study engineered hMxA to restrict multiple human-adapted influenza viruses as effectively as mMx1 by combining nuclear relocalization and specific amino acid changes.

The paper defines the MxA-Thogotovirus nucleoprotein interface using structural modeling and experimental validation, revealing key residues involved in restriction and escape.

The paper uses AlphaFold and molecular dynamics to model Saccharomyces killer toxins, revealing structural homology and functional insights into their mechanisms.

This paper trains a neural network to correct FoldX's free energy predictions for protein folding and binding, significantly improving accuracy for single and double mutations and epistasis.

This study shows deep-sea fish larvae use a hybrid cone-rod photoreceptor type for vision in dim light, revealing an alternative developmental pathway for vertebrate vision.

The paper evaluates predictive models for {Phi}X174 bacteriophage viability using biophysical and molecular modeling approaches, finding that large-effect mutations are highly informative for predicting phenotypes.

This study models how protein stability affects fitness in {phi}X174 bacteriophage using deep mutational scanning and a multistage binomial model, finding that large destabilizing mutations predict inviability but smaller ones do not reliably predict survival.

This study evaluates the MD+FoldX method's ability to predict SARS-CoV-2 antibody escape mutations using a large deep mutational scanning dataset, showing moderate correlation with experimental data.

This study identifies molecular mechanisms behind spectral shifts in zebrafish cone opsins using molecular modeling and quantum mechanics, highlighting key residues and structural features responsible for different absorption wavelengths.

This study identifies six critical amino acids in NUP153 essential for HIV capsid interaction using computational and experimental methods.

The paper identifies and characterizes a novel totivirus, PmV-L-A, in the yeast Pichia membranifaciens, revealing structural and evolutionary relationships with other totiviruses.