Molecular BiologybioRxivPreprint
Hidden stop codons orchestrate mRNA fate by ambushing ribosomal frameshifting associated with codon usage
Zhanbiao Li, Xiaoqian Gu, Shimin Gong…·Yunkun Dang
The paper shows hidden stop codons promote mRNA decay by causing ribosomal frameshifting in fungi and human cells, disrupting circadian rhythms and stabilizing mRNAs with nonoptimal codons.
DOI 10.64898/2026.01.14.699446