Qin Bian

The paper shows hidden stop codons promote mRNA decay by causing ribosomal frameshifting in fungi and human cells, disrupting circadian rhythms and stabilizing mRNAs with nonoptimal codons.

This study identifies the Hippo-YAP/TAZ-TEAD axis as a regulator of bone marrow stromal cell multipotency through computational analysis of single-nucleus multiomics data.

The paper introduces Epoch, a tool for dynamic GRN reconstruction, and shows it identifies topology changes in mouse ESC differentiation networks driven by signaling pathways.

The paper uses single-cell RNA-Seq to map transcriptional programs in synovial joint development, identifying a progenitor population and the role of FGF signaling in chondrocyte fate.

The paper evaluates the transcriptional fidelity of cancer models using a machine learning tool called CancerCellNet, finding that genetically engineered mice and tumoroids generally show higher fidelity than other model types.

The paper constructs a single-cell transcriptional atlas of synovial joint progenitors from E12.5 to E15.5 in mice to uncover transcriptional programs and cell interactions during joint development.