Synergistic interactions of mobile genetic elements shape the stepwise evolution of multidrug-resistant plasmids
Yuqing Mao, Guorui Zhang, Zhou Han, Joanna L. Shisler, Rachel J. Whitaker, Thanh H. Nguyen
This study shows how mobile genetic elements synergistically drive the stepwise accumulation of antibiotic resistance genes in plasmids, proposing a framework to predict and surveil multidrug resistance.
bioRxiv · Nov 28, 2025 · PreprintMicrobiology