Lukas Oesinghaus

The paper introduces CytED, a database that transforms cytokine literature into a resource for experimental analysis, identifying unexpected biological effects and guiding perturbation experiments.

The paper creates a Human Cytokine Dictionary using single-cell transcriptomes of PBMCs stimulated with cytokines, revealing cell-type-specific responses and communication networks.

The paper develops a model to predict mRNA stability based on microRNA expression data and applies it to design microRNA-responsive constructs with specific activity patterns across cell types.

This paper demonstrates a method to control gene expression in mammalian cells using multiplexed conditional guide RNAs for Cas12a, enabling input-dependent activation through various RNA-based mechanisms.