Alyssa La Fleur

A single-cell cytokine dictionary of human peripheral blood

The paper creates a Human Cytokine Dictionary using single-cell transcriptomes of PBMCs stimulated with cytokines, revealing cell-type-specific responses and communication networks.

Massively parallel protein-protein interaction measurement by sequencing (MP3-seq) enables rapid screening of protein heterodimers

The paper introduces MP3-seq, a scalable method for measuring protein-protein interactions, and shows it can quantify over 100,000 interactions.

Interpreting Neural Networks for Biological Sequences by Learning Stochastic Masks

This paper introduces Scrambler networks, a method for interpreting sequence-based neural networks by learning stochastic masks to identify salient sequence positions and explain model predictions.

Multi-Approach and Multi-Scale Model of CD4+ T Cells Predicts Switch-Like and Oscillatory Emergent Behaviors in Inflammatory Response to Infection

The paper develops a multi-scale model of CD4+ T cells integrating multiple modeling approaches to predict switch-like and oscillatory behaviors in inflammatory responses.