Friedrich Christian Simmel

The paper shows that slime mould networks can detect and escape harmful environments through reconfiguration, depending on their size and connectivity.

This paper introduces an experimental method to reconstruct free-energy landscapes of rotary DNA nanomachines using electric-field biasing and statistical reweighting, revealing energy barriers and design modifications' effects.

This paper introduces a DNA origami nanomechanical amplifier that translates molecular conformational changes into measurable mechanical displacements, enabling single-molecule analysis of binding events without labeling or fluorescence.

This paper designs a DNA-based nanoscale Jitterbug transformer that reconfigures its structure in response to chemical and optical signals, maintaining a Poissons ratio of -1.

This paper introduces a high-throughput droplet microfluidics method to quantify individual phage infection events, offering a more accurate understanding of phage-host dynamics.

This study investigates how background nucleic acids affect CRISPR-Cas12a activity, finding that guide RNA GC content and purine fraction influence kinetic inhibition.

This paper demonstrates magnetic DNA origami nanorotors that can be controlled and rotated using magnetic fields, achieving torque values of 10-100 pN nm.

This paper introduces DNA origami membranes that self-assemble into cell-scale containers, enabling programmable compartmentalization for bottom-up biology and soft robotics.

This paper introduces a method to create freestanding DNA shells that mimic lipid membranes, demonstrating their ability to retain geometric features from templates and form tunable compartments.

This study demonstrates the use of GelMA hydrogels for 3D cell culture with in situ genetic manipulation and spatially controlled gene expression.

This study introduces non-natural bases to improve the robustness of strand displacement circuits in complex environments.

This paper uses DNA origami to create a nanoscale metastructure that can switch between frustrated and non-frustrated mechanical states, with distinct free energy profiles.

This study uses a human vasculature-on-chip system to show how flow and VEGF levels affect vascular remodeling and response to anti-VEGF therapy.

The paper presents an optimized protocol for sequencing ultra-short DNA fragments using Oxford Nanopore Technology, improving data quality compared to standard protocols.

This study uses single-molecule force spectroscopy to analyze the kinetics of toehold-mediated strand displacement, revealing sequence-dependent dynamics and load effects in DNA and RNA interactions.

This study shows that DNA origami rotors can function as Brownian motors with intrinsic anisotropy, transitioning to deterministic motion under higher external switching fields.

The paper experimentally demonstrates period doubling and quadrupling in a synthetic genetic oscillator under external perturbations.

The paper studies transcriptional interference in toehold switch-based RNA circuits and demonstrates how promoter arrangement affects gene expression levels.

The paper investigates how synthetic cells can determine their position in a multicellular structure using morphogen gradients and identifies factors limiting positional information.

This paper demonstrates a method to control gene expression in mammalian cells using multiplexed conditional guide RNAs for Cas12a, enabling input-dependent activation through various RNA-based mechanisms.

The paper characterizes a synthetic bacterial oscillator using CRISPRi and shows it produces robust oscillations and affects cellular growth.

This paper designs de-novo RNA-based translational repressors with multi-input logic capabilities for synthetic biology applications.

The paper demonstrates reversible filamentation and restoration of normal growth in E. coli using CRISPRi and antisense RNA, showing population dynamics and gene expression variability.