Membrane potential and feedback dynamics regulate CatSper-mediated progesterone signaling in human sperm
Michelina Kierzek, Dmitry Fridman, Cristina Biagioni, Evan W. Miller, U. Benjamin Kaupp, Christoph Brenker, Timo Strünker
This study investigates how progesterone regulates membrane potential and Ca2+ signaling in human sperm through CatSper and Slo3 channels, revealing feedback mechanisms that control depolarization and repolarization.
bioRxiv · Sep 14, 2025 · PreprintCell Biology