BiophysicsbioRxivPreprint
Structural heterogeneity in mRNA-LNP subpopulations revealed by AF4-SAXS: implications for cargo loading and cell transfection
Adrian Sanchez-Fernandez, Keira A. Donnelly, Hans Bolinsson…·Lars Nilsson
This study uses AF4-SAXS and other techniques to reveal structural heterogeneity in mRNA-LNP subpopulations, showing that N/P ratio affects cargo loading and transfection efficiency.