Systems BiologyPLoS Computational BiologyPeer-reviewed
Efficient computation of adjoint sensitivities at steady-state in ODE models of biochemical reaction networks
Polina Lakrisenko, Paul L. Stapor, Stephan Grein…·Jan Hasenauer
The paper introduces a new adjoint method for computing gradients in ODE models of biochemical reaction networks using steady-state data, achieving up to 4.4x speedup in simulation time for large-scale models.
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