Polina Lakrisenko

PEtab Select provides a standardized format and software for automated model selection in systems biology, supporting diverse modeling frameworks and enabling efficient evaluation of large model spaces.

The paper benchmarks optimization methods for parameter estimation in life sciences, identifying performance tiers and proposing a hybrid strategy that improves solution quality and robustness.

The paper develops a mechanistic model of PKA dynamics in nociceptive neurons to quantify how pro- and anti-nociceptive inputs shape its activity and provides testable predictions for opioid modulation.

The paper introduces a new adjoint method for computing gradients in ODE models of biochemical reaction networks using steady-state data, achieving up to 4.4x speedup in simulation time for large-scale models.