Author

Hari Easwaran

Johns Hopkins UniversityORCID 0000-0002-5517-2972Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:dimensionality reduction· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Approach:matrix factorization· 1

Frequent Co-Authors

Alexander V. FavoroviD· 1 shared Daniel Petkovich· 1 shared Daria A. GaykalovaiD· 1 shared Elana Judith FertigiD· 1 shared Hisashi Ro· 1 shared Jacob Blum· 1 shared Jeff (Tza-Huei) R Wang· 1 shared Lijing Yang· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBioinformatics

Alexander V. FavorovORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintNov 3, 2026

Polycomb Marked Promoter Methylation Gains in Aging and Cancer are Independent of Replication

Hari Easwaran, Sara-Jayne Thursby, Nibedita Patel…·Stephen Bruce Baylin

This study shows that Polycomb-marked promoter methylation gains in aging and cancer occur independently of replication and are driven by age-related epigenetic drift rather than oncogenic signaling.

DOI 10.64898/2026.10.30.763235

mouseDNA methylation

BioinformaticsNucleic Acids ResearchPeer-reviewedApr 25, 2020

Matrix factorization and transfer learning uncover regulatory biology across multiple single-cell ATAC-seq data sets

Rossin Erbe, Michael D. Kessler, Alexander V. Favorov…·Elana Judith Fertig

This study integrates multiple scATAC-seq datasets using matrix factorization and transfer learning to identify common regulatory patterns across datasets.

12 citations

scATAC-seqmatrix factorization