BioinformaticsPLoS Computational BiologyPeer-reviewed
Monotherapy cancer drug-blind response prediction is limited to intraclass generalization
William G. Herbert, Nicholas Chia, Paul A. Jensen, Marina R. S. Walther-Antonio
This paper quantifies the limitations of drug-blind prediction in cancer DRP models, showing that generalization relies on mechanistic overlap and that performance is more about dataset behavior than model behavior.
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