DNA methylation variability provides a complementary epigenetic signature of aging heterogeneity: Findings from the Canadian Longitudinal Study on Aging and the Baltimore Longitudinal Study of Aging
Olga Vishnyakova, Joosung Min, Ann Zenobia Moore, T Toshiko, Luigi Ferrucci, Xiaowei Song, Kenneth J. Rockwood, Angela Brooks-Wilson, Lloyd T. Elliott
The paper identifies DNA methylation variability and differential methylation regions associated with aging-related health decline and constructs an epigenetic biomarker that outperforms methylation-only biomarkers in predicting mortality.
The Journals of Gerontology Series A · Sep 17, 2026Peer-reviewedGenomics