The paper identifies DNA methylation variability and differential methylation regions associated with aging-related health decline and constructs an epigenetic biomarker that outperforms methylation-only biomarkers in predicting mortality.

The Journals of Gerontology Series A · Sep 17, 2026Peer-reviewedGenomics

The blood proteome predicts the impact of circulating factors on age-related mitochondrial health

Stephanie Heimler, Jaclyn Bergstrom, Nina Sun, Toshiko Tanaka, Ann Zenobia Moore, Julián Candia, Brian H. Chen, Qu Tian, Arsun Bektas, Giovanna Fantoni, Christopher Dunn, Mary Kaileh, Ranjan Sen, Luigi Ferrucci, Anthony J. A. Molina

The paper develops a proteomic signature, MitoAge, that predicts age-related mitochondrial health based on circulating factors in serum.

npj Aging · Jul 24, 2026Peer-reviewedCell Biology

Compatibility and comparative analysis of chronological and biological aging between the legacy 450K and the EPIC v2.0 arrays

Sven Jiulien Maria de Pourcq, Pei‐Lun Kuo, Ann Zenobia Moore, Stefania Bandinelli, Steve Horvath, Luigi Ferrucci, Valeria Santini

The paper compares epigenetic aging estimates between the 450K and EPICv2 arrays, finding that some clocks are affected by missing probes, but overall correlations remain strong.

Mechanisms of Ageing and Development · Dec 5, 2025Peer-reviewedGenetics

Systems Age: A single blood methylation test to quantify aging heterogeneity across 11 physiological systems

Raghav Sehgal, Yaroslav Markov, Chenxi Qin, Margarita V. Meer, Courtney Hadley, Aladdin H. Shadyab, Ramon Casanova, JoAnn E. Manson, Parveen Bhatti, Ann Zenobia Moore, Eileen M. Crimmins, Sara Hägg, Themistocles L. Assimes, Eric A. Whitsel, Albert Higgins‐Chen, Morgan E. Levine

The paper develops 11 system-specific methylation clocks from blood samples to quantify aging heterogeneity across physiological systems and identifies aging subtypes with distinct disease patterns.

Nature Aging · Sep 15, 2025Peer-reviewedSystems Biology

Characterization of DNA methylation in PBMCs and donor-matched iPSCs shows methylation is reset during stem cell reprogramming

Xylena Reed, Cory A. Weller, Sara Sáez-Atiénzar, Alexandra G. Beilina, Sultana Solaiman, Makayla K. Portley, Mary Kaileh, Roshni Roy, Jinhui Ding, Ann Zenobia Moore, D. Thad Whitaker, Bryan J. Traynor, Jesse Raphael Gibbs, Sonja W. Scholz, Mark Cookson

The paper shows that DNA methylation is reset in iPSCs compared to donor PBMCs, with unique methylation sites influenced by genetics in each cell type.

bioRxiv · Dec 13, 2024 · PreprintMolecular Biology

Epigenetic signature of human immune aging: the GESTALT study.

Roshni Roy, Pei‐Lun Kuo, Julián Candia, Dimitra Sarantopoulou, Ceereena Ubaida‐Mohien, Dena G. Hernandez, Mary Kaileh, Sampath Arepalli, Amit Singh, Arsun Bektas, Jae‐Kwan Kim, Ann Zenobia Moore, Toshiko Tanaka, Julia McKelvey, Linda M. Zukley, , Luigi Ferrucci

The paper identifies age-associated DNA methylation sites in immune cells and links them to transcription factor motifs and histone modifications, suggesting adaptive responses to oxygen fluctuations in aging.

eLife · Aug 17, 2023Peer-reviewedMolecular Biology

Personality traits are consistently associated with blood mitochondrial DNA copy number estimated from genome sequences in two genetic cohort studies

Richard Oppong, Antonio Terracciano, Martin A. Picard, Yong Qian, Thomas J Butler, Toshiko Tanaka, Ann Zenobia Moore, Eleanor Marie Simonsick, Krista Opsahl-Ong, Christopher E. Coletta, Angelina R. Sutin, Myriam Gorospe, Susan M. Resnick, Francesco Cucca, Sonja W. Scholz, , Jun Ding

This study finds that blood mitochondrial DNA copy number is consistently associated with personality traits and mediates the link between personality and mortality in two genetic cohorts.

eLife · Nov 7, 2022Peer-reviewedGenetic & Genomic Medicine

A computational solution for bolstering reliability of epigenetic clocks: Implications for clinical trials and longitudinal tracking

Albert Higgins‐Chen, Kyra Thrush, Yunzhang Wang, Christopher J. Minteer, Pei‐Lun Kuo, Meng Wang, Peter Niimi, Gabriel Sturm, Jue Lin, Ann Zenobia Moore, Stefania Bandinelli, Christiaan H. Vinkers, Eric H. G. J. M. Vermetten, Bart P. F. Rutten, Elbert Geuze, , Morgan E. Levine

This paper introduces a computational method to improve the reliability of epigenetic clocks by using principal component analysis, showing reduced technical noise and better performance in longitudinal studies.

Nature Aging · Jul 15, 2022Peer-reviewedBioinformatics

Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

Daniel L. McCartney, Josine L. Min, Rebecca Claire Richmond, Ake Tzu-Hui Lu, Maria Sobczyk, Gail Davies, Linda Broer, Xiuqing Guo, Ayoung Jeong, Jeesun Jung, Silva Kasela, Şeyma Katrinli, Pei‐Lun Kuo, Pamela R. Matías‐García, Pashupati Prasad Mishra, , Jerome I. Rotter

This study identifies 137 genome-wide significant loci associated with DNA methylation biomarkers of ageing using DNAm and SNP data from over 41,000 individuals.

bioRxiv · Jun 29, 2020 · PreprintGenetics

Novel DNA methylation sites of glucose and insulin homeostasis: an integrative cross-omics analysis

Jun Liu, Elena Carnero‐Montoro, Jenny van Dongen, Samantha Lent, Ivana Nedeljkovic, Symen Ligthart, Pei-Chien Tsai, Tiphaine C. Martin, Pooja R. Mandaviya, Rick Jansen, Marjolein J. Peters, Liesbeth Duijts, Vincent W. V. Jaddoe, Henning W. Tiemeier, Janine F. Felix, , Cornelia M. van Duijn

This study identifies nine novel DNA methylation sites associated with fasting glucose and insulin levels by integrating cross-omics data from multiple cohorts.

Nature Communications · Jun 13, 2019Peer-reviewedGenomics