Integrating computational protein structure predictions and genetic dependencies yields an atlas of human multi-protein complexes (AHMPC)
Michael Uckelmann, Daniel Álvarez Salmoral, Carmen Maiella, Onno B. Bleijerveld, Ceri Zwart, Eric Marcus, Joren Brunekreef, Jonas Teuwen, Roderick L. Beijersbergen, Anastassis Perrakis A
The paper constructs an atlas of human multi-protein complexes by integrating computational structure predictions with genetic dependency data, identifying 354 high-confidence complexes including novel ones.
bioRxiv · Sep 9, 2025 · PreprintBiochemistry