Onno B. Bleijerveld

This study identifies SMIM1 as a key regulator of an alternative iron uptake pathway through hemoglobin binding and lysosomal iron release, with implications for iron homeostasis and erythropoiesis.

The paper constructs an atlas of human multi-protein complexes by integrating computational structure predictions with genetic dependency data, identifying 354 high-confidence complexes including novel ones.

The paper shows TRIM33 enhances AR activity by reducing H2BK120 ubiquitination, without affecting AR protein stability.

This study shows that targeting DOT1L and EZH2 together disrupts the germinal center identity of GCB-DLBCL cells, leading to a cell-identity crisis and reduced tumor growth in vivo.

The paper shows that mitochondrial damage can induce therapy-induced senescence in GBM cells through a ROS-cGAS-STING-SASP cascade, outperforming single or dual pathway inhibitors.

This paper identifies SLC25A23 as a vulnerability in senescent cancer cells and shows that salinomycin induces immunogenic cell death, enhancing immune destruction of these cells when combined with a DR5 agonistic antibody.