Álvaro Lladser

SPARE audits single-cell RNA-seq zero imputation by categorizing edits as edited, unchanged, or marker-vetoed, improving biological validity over reconstruction accuracy.

The paper identifies three CD8+ T cell subsets in ccRCC and links their differentiation states to clinical outcomes.

scExplorer is a web-based tool that simplifies scRNA-seq analysis by providing an interactive platform for preprocessing, dimensional reduction, and differential expression analysis.

This study shows that host CD8+ T cells enhance adoptive cell therapy (ACT) efficacy against melanoma, while lymphodepleting preconditioning reduces long-term effectiveness by impairing host immunity.