Junctophilin-2 promotes cardiomyocyte survival by blocking MURF1-mediated Junctin ubiquitination and proteasome-dependent degradation
Xiaoyun Ji, Yifan Huang, Rui Ni, Dong Zheng, Guo‐Chang Fan, Douglas L. Jones, Long‐Sheng Song, Subrata Chakrabarti, Zhaoliang Su, Tianqing Peng
This study shows junctophilin-2 protects cardiomyocytes from stress by preventing junctin ubiquitination and degradation, maintaining Ca2+ homeostasis and reducing apoptosis.
bioRxiv · Oct 23, 2022 · PreprintMolecular Biology