The paper introduces a diploid genomic foundation model to represent diploid genotypes in genomic language models, improving variant discrimination in compound-heterozygous cases.

bioRxiv · Sep 11, 2026 · PreprintBioinformatics

GFMBench-API: A Standardized Interface for Benchmarking Genomic Foundation Models

Ariel Larey, Elay Dahan, Amit Bleiweiss, Raizy Kellerman, Guy Leib, Omri Nayshool, Dan Ofer, Tal Zinger, Dan Dominissini, Gideon Rechavi, Nicole Bussola, Simon Lee, Shane O’Connell, Dung T. Hoang, Marissa Wirth, , Nati Daniel

Wrap a genomic foundation model's inference methods once to score it on supervised and zero-shot GUE, VariantBenchmarks, BEND, TraitGym and ClinVar tasks; code is promised upon acceptance.

bioRxiv · Aug 11, 2026 · PreprintGenomics✦ In-depth digest

i6A-seq maps N6-isopentenyladenosine and uncovers its role as a regulator of mRNA stability through recruitment of DIS3L2

Chen Avrahami, Louisa Cohen Ben-Aderet, Reut Fluss, Rula Masoud, Omri Nayshool, Tal Zinger, Michal Sevilla-Sharon, Efrat G. Saar, Asher Yahalom A, Laia Coll-SanMartin, Manel Esteller, Gideon Rechavi, Dan Dominissini, Sharon Moshitch-Moshkovitz

The paper introduces i6A-seq, a method to map N6-isopentenyladenosine in mRNA, revealing its role in mRNA stability via DIS3L2 recruitment.

bioRxiv · Nov 26, 2025 · PreprintMolecular Biology