i6A-seq maps N6-isopentenyladenosine and uncovers its role as a regulator of mRNA stability through recruitment of DIS3L2
Chen Avrahami, Louisa Cohen Ben-Aderet, Reut Fluss, Rula Masoud, Omri Nayshool, Tal Zinger, Michal Sevilla-Sharon, Efrat G. Saar, Asher Yahalom A, Laia Coll-SanMartin, Manel Esteller, Gideon Rechavi, Dan Dominissini, Sharon Moshitch-Moshkovitz
The paper introduces i6A-seq, a method to map N6-isopentenyladenosine in mRNA, revealing its role in mRNA stability via DIS3L2 recruitment.
bioRxiv · Nov 26, 2025 · PreprintMolecular Biology