Manel Esteller

This study uses spatial transcriptomics to analyze lung tissue from fatal COVID-19 cases, identifying cellular and molecular changes during disease progression.

This paper develops GepiClock, an epigenetic clock for cancer cells, revealing age-related therapeutic vulnerabilities in cancer cell lines.

This study identifies IL-16 production as a mechanism of resistance to BTK inhibitors and R-CHOP in lymphomas, showing that targeting the IL-16/CD9 axis restores drug sensitivity.

The paper shows ibrutinib increases CD19 expression in B-cell lymphoma models, improving the effectiveness of CD19-CAR T cells.

This study identifies a diet-imprinted macrophage-tumor circuit driven by the CAMP-P2RX7 axis that promotes pancreatic cancer initiation, plasticity, and metastasis.

This study identifies BC-markers in TNBC, links them to poor prognosis and dasatinib sensitivity, suggesting TAGLN as a predictive biomarker for targeted therapy.

The paper introduces i6A-seq, a method to map N6-isopentenyladenosine in mRNA, revealing its role in mRNA stability via DIS3L2 recruitment.

The paper benchmarks DNA methylation sequencing workflows against an experimental gold-standard, identifying superior workflows and developing a sustainable benchmarking platform.

This study identifies METTL3-mediated m6A modification of DNMT1 as a driver of ovarian cancer progression by enhancing DNMT1 translation and suppressing tumor suppressors.

This study presents a multi-omics analysis of a supercentenarian, revealing that extreme age and poor health are distinct molecular processes.

The paper trains an ensemble classifier to predict cetuximab sensitivity in colorectal cancer PDXs using multi-omic data, achieving high accuracy and demonstrating its utility for therapeutic biomarker development.

This study identifies TET2-mutant clonal hematopoiesis in thyroid cancer microenvironments and shows that TGFβ signaling from these macrophages mediates resistance to BRAF/MEK inhibition, with TGFβ inhibition restoring sensitivity.

This study benchmarks spatial transcriptomics and proteomics platforms across six cancer types, identifying platform-specific strengths and limitations in data quality and biological insights.

The paper identifies lipid-related genetic mechanisms contributing to white matter hyperintensities in middle-aged individuals at low risk for late-life dementia.

The paper identifies brain structure signatures linked to Alzheimer's genetic risk across disease stages using compositional data analysis.

This study identifies epigenetic and transcriptomic changes in SLE monocyte subsets, linking them to disease activity and function.

The paper characterizes the genetic profiles of ALFA participants, showing high AD genetic risk and similarity to clinical groups along the AD continuum.

This study identifies cell-type-specific epigenetic changes in TNXB in Alzheimer's disease using bulk and single-cell analyses of the dorsal raphe nucleus.

This study shows that LSD1's non-catalytic function regulates DNA methylation in mouse ESCs by controlling UHRF1 and DNMT1 stability through USP7 interaction.

The paper identifies NOTCH1-JAG1 cis interactions regulated by RADICAL FRINGE that maintain hematopoietic stem cell fate during development.

The paper identifies 34 DNA methylation CpGs associated with acute myocardial infarction and validates four for coronary and cardiovascular disease, but finds no improvement in predictive capacity over existing models.

This study identifies 20 novel loci associated with ischemic stroke through an epigenome-wide association study, highlighting methylation changes in pathways like inflammation and lipid metabolism.

This study shows that pro-inflammatory cytokines reveal plasticity in β-cell regulatory landscapes and identify T1D-associated variants disrupting cytokine-responsive enhancers.

This study identifies SirT7's dual role as a deacetylase and mADPRT enzyme, showing its regulation of glucose starvation response via interaction with macroH2A1.1.

This study identifies two molecular subgroups of anaplastic meningioma with distinct survival outcomes and links them to specific genetic mutations.