Metabolic Rigidity as a Mechanical Barrier to Malaria: Flickering Loss in PKLR-Deficient Erythrocytes
Natalia Hernando‐Ospina, Macarena Calero, Guillermo Solís‐Fernández, Isabel G. Azcárate, Diego Herráez‐Aguilar, Niccolò Caselli, Lara H. Moleiro, Jose Carlos Segovia, José Manuel Bautista, Francisco Monroy
This study shows that PKLR-deficient erythrocytes, due to metabolic rigidity, resist Plasmodium yoelii infection by maintaining mechanical properties that hinder parasite-induced membrane changes.
The FASEB Journal · Nov 19, 2025Peer-reviewedBiophysics