Guillermo Solís‐Fernández

Synthetic Fibrous Hydrogels as Minimal Systems to Modulate Cell Migration Modes in 3D

This paper introduces tunable fibrous hydrogels to study how specific ligands direct different cell migration modes in 3D environments.

Quantitative Analysis of Cytoplasmic Viscosity in Colorectal Cancer Cells by Differential Dynamic Microscopy of Genetically Encoded Nanoparticles

This paper introduces GEM-DDM, a method using genetically encoded nanoparticles and differential dynamic microscopy to measure cytoplasmic viscosity in living cells, showing increased viscosity in aggressive colorectal cancer cells.

Deciphering stiffness-driven changes in colorectal cancer by proteomics

This study shows that matrix stiffness in colorectal cancer alters secreted protein expression, enhancing migration, angiogenesis, and matrix remodeling, contributing to a more aggressive cancer phenotype.

Label-Free Monitoring of Cancer-associated Fibroblast Activation using NADH Fluorescence Lifetime Imaging

This study uses NADH fluorescence lifetime imaging to monitor dynamic changes in cancer-associated fibroblast activation in real-time without labels.

Metabolic Rigidity as a Mechanical Barrier to Malaria: Flickering Loss in PKLR-Deficient Erythrocytes

This study shows that PKLR-deficient erythrocytes, due to metabolic rigidity, resist Plasmodium yoelii infection by maintaining mechanical properties that hinder parasite-induced membrane changes.