Author

Lena F. Schimke

Universidade de São PauloORCID 0000-0002-5616-3410Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Molecular Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Organism:human· 3 Approach:statistical model· 2 Research Focus:benchmarking· 1 Approach:machine learning (classical)· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Adriel Leal NóbileiD· 3 shared Anny Silva AdriiD· 3 shared Dennyson Leandro M. FonsecaiD· 3 shared Fernando Yuri Nery do ValeiD· 3 shared Gustavo Cabral‐MirandaiD· 3 shared Haroldo Dutra DiasiD· 3 shared Helder Imoto NakayaiD· 3 shared Igor Salerno FilgueirasiD· 3 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMolecular Biology

Adriel Leal NóbileORCID

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3 papers

Recent·Most cited

Molecular BiologybioRxivPreprintMar 12, 2026

HTLV-1-Induced Neuroimmunome Correlates with Disease Progression and Severity

Fernando Yuri Nery do Vale, Carlota Miranda-Solé, Adriel Leal Nóbile…·Otávio Cabral-Marques

The paper identifies a neuroimmune signature in HTLV-1 infection that correlates with disease progression and severity using bulk and single-cell transcriptomic data.

DOI 10.64898/2026.03.12.711373

humanbulk RNA-seq

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Systems BiologyTranslational PsychiatryPeer-reviewedNov 29, 2025

Integrative systems neuroimmunology reveals leukocyte-expressing PAX6 as a critical predictor of major depressive disorder

Haroldo Dutra Dias, Anny Silva Adri, Adriel Leal Nóbile…·Otávio Cabral-Marques

This study identifies PAX6 as a critical predictor of MDD using transcriptomic data from 3,114 individuals and validates its expression in PBMCs and the amygdala.

3 citations

humanbulk RNA-seq

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BioinformaticsbioRxivPreprintNov 13, 2024

Dysregulation of synaptic-related genes within neuroimmune networks of peripheral blood mononuclear cells in major depressive disorder

Anny Silva Adri, Adriel Leal Nóbile, Débora Gomes de Alburquerque…·Otávio Cabral-Marques

The paper identifies synaptic-related gene dysregulation in PBMCs of MDD patients, highlighting shared molecular signatures with brain regions and potential biomarkers for depression.

1 citation

humanbulk RNA-seq

𝕏 PostBluesky