Otávio Cabral-Marques

From mice to humans: A multi-omic predictive framework for translational immunology

This paper develops a multi-omic framework to predict human immune responses from mouse models across various stimuli, finding that functional modules are more conserved than individual genes.

HTLV-1-Induced Neuroimmunome Correlates with Disease Progression and Severity

The paper identifies a neuroimmune signature in HTLV-1 infection that correlates with disease progression and severity using bulk and single-cell transcriptomic data.

Integrative systems neuroimmunology reveals leukocyte-expressing PAX6 as a critical predictor of major depressive disorder

This study identifies PAX6 as a critical predictor of MDD using transcriptomic data from 3,114 individuals and validates its expression in PBMCs and the amygdala.

Dysregulation of synaptic-related genes within neuroimmune networks of peripheral blood mononuclear cells in major depressive disorder

The paper identifies synaptic-related gene dysregulation in PBMCs of MDD patients, highlighting shared molecular signatures with brain regions and potential biomarkers for depression.

Muscle cell atrophy induced by miR-155-5p reveals molecular targets in skeletal muscle disorders

The paper identifies miR-155-5p-induced gene expression changes in muscle atrophy and links them to disease-related pathways in skeletal muscle disorders.