Dennyson Leandro M. Fonseca

This study identifies HIF-1α as a regulator of metabolic and immunoregulatory programs in RORγt⁺ Tregs during intestinal inflammation, showing its role in maintaining suppressive function and limiting inflammation.

This study identifies miR-721 as a host regulator that suppresses the TNF-IRF1 axis in Leishmania-infected macrophages, promoting parasite persistence.

The paper identifies a neuroimmune signature in HTLV-1 infection that correlates with disease progression and severity using bulk and single-cell transcriptomic data.

This study uses single-cell RNA sequencing to show that checkpoint inhibitors like anti-CTLA-4 and anti-PD-1 shift the lung immune response in PCM toward a Th17-driven program involving neutrophils and macrophages, enhancing antifungal immunity.

This study identifies PAX6 as a critical predictor of MDD using transcriptomic data from 3,114 individuals and validates its expression in PBMCs and the amygdala.

The paper identifies synaptic-related gene dysregulation in PBMCs of MDD patients, highlighting shared molecular signatures with brain regions and potential biomarkers for depression.