Zebrafish models of Mucopolysaccharidosis IIIA, IIIB, and IIIC show hyperactivity, neuroinflammation and changes in oligodendrocyte cell state
Ewan Gerken, Syahida Ahmad, Lakshay Rattan, Kim M. Hemsley, Angel G Allen, Adeline A. Lau, Karissa Barthelson, Michael T. Lardelli
This study creates zebrafish models of MPS IIIA, IIIB, and IIIC, revealing hyperactivity, neuroinflammation, and oligodendrocyte changes similar to human disease.
bioRxiv · Aug 2, 2023 · PreprintNeuroscience