Karissa Barthelson

The paper compares transcriptome and proteome changes in zebrafish models of early-onset familial Alzheimer's disease and Sanfilippo syndrome, identifying shared disease pathways.

The paper introduces a method to identify eQTLs and improve transcriptome analysis by quantifying differential allelic representation in RNA-sequencing data.

This study creates zebrafish models of MPS IIIA, IIIB, and IIIC, revealing hyperactivity, neuroinflammation, and oligodendrocyte changes similar to human disease.

The paper describes a plasmid, pHAPE, that allows the generation of DNA size markers through restriction enzyme digestions, reducing costs associated with commercial DNA ladders.

The paper examines how loss of park7 activity affects IRE gene sets in zebrafish, suggesting iron dyshomeostasis and oxidative stress may differentially impact 5' and 3' UTR IREs in Parkinson's disease.

The paper compares the effects of two PSEN1 mutations in zebrafish brains, finding distinct impacts on energy metabolism and signaling pathways linked to different diseases.

The paper compares the effects of frameshift and frame-preserving mutations in zebrafish psen2 on gene expression in young adult brains, identifying distinct cellular pathways affected.

This study investigates the effects of a SORL1 mutation in zebrafish, identifying changes in mitochondrial and ribosome function without affecting APP-related proteins or mitochondrial content.

The paper investigates the molecular effects of SORL1 mutations in zebrafish, identifying both loss- and gain-of-function impacts on brain transcriptomes related to AD.

The paper analyzes the transcriptome of zebrafish with a psen2 mutation to identify dominant effects on ribosome, mitochondrial, and anion transport functions.