Quantitative systems pharmacology modeling of pyrrolobenzodiazepine antibody-drug conjugates targeting BCMA
Inez Lam, David Dai, Rosalinda H. Arends, Venkatesh Pilla Reddy, Kathryn Ball, Feilim Mac Gabhann
The paper develops a quantitative systems pharmacology model to analyze ADCs, showing that bystander effects are significant in vivo and highlighting key design parameters for optimizing efficacy and toxicity.
bioRxiv · Feb 20, 2025 · PreprintSystems Biology